Legionella pneumophila induced IFNβ in lung epithelial cells via IPS-1 and IRF3 which also control bacterial replication*
نویسندگان
چکیده
Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Department of Dermatology and Allergy, Allergy Center Charité, Charité Universitätsmedizin Berlin, Schumannstraße 20/21, 10117 Berlin, Germany; Institute of Biochemistry Charité, Monbijoustrasse 2, 10117 Berlin, Germany; Clinical and Experimental Pathology, Research Center Borstel, Parkallee 3, 23845 Borstel, Germany, Germany Robert Koch-Institute, Research Group NG5 Pathogenesis of Legionella Infections, Nordufer 20, D-13353 Berlin, Germany
منابع مشابه
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.
Legionella pneumophila, a Gram-negative facultative intracellular bacterium, causes severe pneumonia (Legionnaires' disease). Type I interferons (IFNs) were so far associated with antiviral immunity, but recent studies also indicated a role of these cytokines in immune responses against (intracellular) bacteria. Here we show that wild-type L. pneumophila and flagellin-deficient Legionella, but ...
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